منابع مشابه
Chromosomes and Expression Mechanisms Editorial Overview
Introduction Whether one considers a single cell or a multicellular organism, a complex and precisely coordinated series of regulatory events and communications is required to ensure its proper configuration and function. One of the major goals in biology is to understand how cells differentiate into specific types to perform their roles in vivo. Genome sequencing projects have produced enormou...
متن کاملEditorial: Murine Models of Leukemia and Lymphoma
Murine models serve as an effective way to mimic the in vivo tumor microenvironmental interactions that take place in patients with leukemias and lymphomas. Specifically, leukemias and lymphomas rely heavily on the surrounding stroma and tissue microenvironmental cytokine and chemokine signals to ensure survival and expansion of tumor cells. Finally, leukemic cells migrate thanks to signals fro...
متن کاملDouble minute chromosomes in acute myeloblastic leukemia.
Two patients with acute myeloblastic leukemia (AML) with double minute chromosomes (dmins) are described. One patient had dmins in approximately one-third of bone marrow cells examined at diagnosis; no other karyotypic changes were observed. The dmins disappeared when the patient achieved a complete remission. The second patient developed acute leukemia as a second cancer, having previously rec...
متن کاملChromosomes in lymphatic leukemia of C58 mice.
A larger size of chromosomes in neoplastic cells than in cells of the corresponding normal tissues has been observed in a number of instances (2, 4, 6, 8, 9, 11, 13). Among the several proposed explanations, that of Biesele, Poyner, and Painter (9) suggested that the chromosomes of malignant cells contained muhiples of the number of chromosome strands present in those of normal cells. In order ...
متن کاملChromosomes and Causation of Human Cancer and Leukemia
Three male patients with leukemia were found with banding techniques to have unusual cytogenetic pictures in the cells of their marrow, spleen or blood. Case No. 1 (78 yr old) was that of a Ph’-negative CML with a missing Y in the blood (cultured without PHA) and marrow cells. The patient is still alive and responding to therapy. Case No. 2 (54 yr old) was considered prior to admission to have ...
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ژورنال
عنوان ژورنال: Blood
سال: 1964
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v23.3.394.394